Samuel Jackson Gets It On with a Stewardess in a Pile of Dead Snakes

is my prediction for the ending of "Snakes on a Plane". Timothy McSweeney has a list of surprise endings he would like to see. My favorite:

Scenario Three
While on the bus ride home from the airport, Jackson notices the bus driver seems nervous. The driver informs him that if the bus goes slower than 55 mph, snakes will drop from the ceiling. Samuel looks directly at the camera and says, "Here we go again!"